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modafinil will minimize the level or impact of pacritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.modafinil will minimize the level or effect of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with average CYP3A4 inducers is unavoidable, contin